Berberine and Lisinopril
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Needs Verification |
| Interaction Type | SAFETY CONCERN |
| Last Reviewed | 2026-02-24 |
CYP Enzyme Pathway Overlap
Berberine and Lisinopril share activity on the following CYP enzymes:
| Enzyme | Berberine | Lisinopril |
|---|---|---|
| CYP3A4 | INHIBITOR (STRONG) | SUBSTRATE (WEAK) |
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | Berberine | Lisinopril |
|---|---|---|---|
| BLOOD PRESSURE | DECREASE | MODERATE | STRONG |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
What We Don't Know
This interaction has needs verification evidence. Key gaps may include: direct clinical trial data for this specific combination, dose-response relationships, and long-term outcome data. Absence of evidence is not evidence of absence.
API Reference
GET https://api.truthstack.co/v1/check?c1=berberine&c2=Lisinopril
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 38928095
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.