Berberine and Simvastatin

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeMETABOLIC
MechanismMETABOLISM
Last Reviewed2026-02-24

Summary

Berberine inhibits CYP3A4, the primary metabolic pathway for simvastatin. Simvastatin is particularly sensitive to CYP3A4 inhibition. Risk of myopathy. Monitor for muscle pain.

CYP Enzyme Pathway Overlap

Berberine and Simvastatin share activity on the following CYP enzymes:

EnzymeBerberineSimvastatin
CYP3A4INHIBITOR (STRONG)SUBSTRATE (STRONG)

API Reference

GET https://api.truthstack.co/v1/check?c1=Berberine&c2=Simvastatin

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 24782411

Related Interactions

Bergamot + Simvastatin Grapefruit Extract + Simvastatin Red Yeast Rice + Simvastatin Atorvastatin + Berberine Berberine + Lovastatin Berberine + Metformin Berberine + Omeprazole Berberine + Warfarin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.