Atorvastatin and Berberine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | METABOLIC |
| Mechanism | METABOLISM |
| Last Reviewed | 2026-02-24 |
Summary
Berberine inhibits CYP3A4, the primary metabolic pathway for atorvastatin. May increase statin plasma levels and elevate risk of myopathy and rhabdomyolysis. Monitor for muscle pain.
CYP Enzyme Pathway Overlap
Atorvastatin and Berberine share activity on the following CYP enzymes:
| Enzyme | Atorvastatin | Berberine |
|---|---|---|
| CYP3A4 | SUBSTRATE (STRONG) | INHIBITOR (STRONG) |
API Reference
GET https://api.truthstack.co/v1/check?c1=Atorvastatin&c2=Berberine
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 24782411
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.