CBD and Melatonin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | LOW |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-15 |
Summary
CBD modulates endocannabinoid system; melatonin signals circadian sleep. Can combine for sleep; keep CBD dose low
CYP Enzyme Pathway Overlap
CBD and Melatonin share activity on the following CYP enzymes:
| Enzyme | CBD | Melatonin |
|---|---|---|
| CYP1A2 | SUBSTRATE (MODERATE) | SUBSTRATE (STRONG) |
| CYP2C19 | INHIBITOR (STRONG) | SUBSTRATE (WEAK) |
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | CBD | Melatonin |
|---|---|---|---|
| CNS DEPRESSION | INCREASE | MODERATE | MODERATE |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
API Reference
GET https://api.truthstack.co/v1/check?c1=CBD&c2=Melatonin
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.