Carbamazepine and Cbd
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-15 |
Summary
CBD inhibits CYP3A4, potentially increasing carbamazepine levels. Toxicity risk. Also note: carbamazepine induces CYP3A4, reducing CBD levels. Discuss with your prescriber or pharmacist.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Cbd: CYP1A2 substrate (moderate), CYP2C19 inhibitor (strong), CYP2C9 inhibitor (moderate), CYP2D6 inhibitor (moderate), CYP3A4 inhibitor (strong), P-gp inhibitor (moderate)
API Reference
GET https://api.truthstack.co/v1/check?c1=carbamazepine&c2=cbd
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.