Cbd and Cyclosporine

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeCONTRAINDICATED
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

CBD inhibits CYP3A4. Cyclosporine is CYP3A4-dependent. Unpredictable level increases causing nephrotoxicity. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining without transplant team supervision.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Cbd: CYP1A2 substrate (moderate), CYP2C19 inhibitor (strong), CYP2C9 inhibitor (moderate), CYP2D6 inhibitor (moderate), CYP3A4 inhibitor (strong), P-gp inhibitor (moderate)

API Reference

GET https://api.truthstack.co/v1/check?c1=cbd&c2=cyclosporine

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Bergamot + Cyclosporine Cbd + Tacrolimus Cbd + Warfarin Cyclosporine + Echinacea Cyclosporine + Goldenseal Cyclosporine + Grapefruit Extract Cyclosporine + Piperine Cyclosporine + Quercetin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.