CBD and Ibuprofen

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeMETABOLIC
MechanismMETABOLISM
Last Reviewed2026-02-24

Summary

CBD inhibits CYP2C9, primary ibuprofen metabolic pathway. May increase ibuprofen levels and GI bleeding risk.

CYP Enzyme Pathway Overlap

CBD and Ibuprofen share activity on the following CYP enzymes:

EnzymeCBDIbuprofen
CYP2C9INHIBITOR (MODERATE)SUBSTRATE (STRONG)

API Reference

GET https://api.truthstack.co/v1/check?c1=CBD&c2=Ibuprofen

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Cbd + Cyclosporine Cbd + Tacrolimus Cbd + Warfarin Alprazolam + Cbd Carbamazepine + Cbd Cbd + Citalopram Cbd + Clonazepam Cbd + Duloxetine
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.