Berberine and Fluoxetine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | METABOLIC |
| Mechanism | METABOLISM |
| Last Reviewed | 2026-02-24 |
Summary
Berberine inhibits CYP2D6. Both are CYP2D6 inhibitors. Monitor for increased side effects.
CYP Enzyme Pathway Overlap
Berberine and Fluoxetine share activity on the following CYP enzymes:
| Enzyme | Berberine | Fluoxetine |
|---|---|---|
| CYP2C9 | INHIBITOR (MODERATE) | INHIBITOR (MODERATE) |
| CYP2D6 | INHIBITOR (MODERATE) | INHIBITOR (STRONG) |
API Reference
GET https://api.truthstack.co/v1/check?c1=Berberine&c2=Fluoxetine
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.