Atorvastatin and Cbd
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | ANTAGONISTIC |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-15 |
Summary
CBD inhibits CYP3A4, potentially increasing atorvastatin levels. Monitor for muscle pain and weakness. Consider rosuvastatin or pravastatin as alternatives.
CYP Enzyme Pathway Overlap
Atorvastatin and Cbd share activity on the following CYP enzymes:
| Enzyme | Atorvastatin | Cbd |
|---|---|---|
| CYP3A4 | SUBSTRATE (STRONG) | INHIBITOR (STRONG) |
API Reference
GET https://api.truthstack.co/v1/check?c1=atorvastatin&c2=cbd
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.