Alprazolam and Berberine

Supplement–drug interaction evidence from the TruthStack database.

SeverityLOW
Evidence TierModerate
Interaction TypeMETABOLIC
MechanismMETABOLISM
Last Reviewed2026-02-24

Summary

Berberine inhibits CYP3A4 which metabolizes alprazolam. Modest potential for increased sedation.

CYP Enzyme Pathway Overlap

Alprazolam and Berberine share activity on the following CYP enzymes:

EnzymeAlprazolamBerberine
CYP3A4SUBSTRATE (STRONG)INHIBITOR (STRONG)

API Reference

GET https://api.truthstack.co/v1/check?c1=Alprazolam&c2=Berberine

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Atorvastatin + Berberine Berberine + Lovastatin Berberine + Metformin Berberine + Omeprazole Berberine + Simvastatin Berberine + Warfarin Alprazolam + Cbd
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.