Kava and Warfarin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SAFETY CONCERN |
| Mechanism | METABOLISM |
| Last Reviewed | 2026-02-24 |
Summary
Kava has documented hepatotoxic potential and inhibits multiple CYP enzymes. May unpredictably alter warfarin metabolism.
Higher-Concern Contexts
This interaction may be of particular concern in the following contexts:
- anticoagulant use
CYP Enzyme Pathway Overlap
Kava and Warfarin share activity on the following CYP enzymes:
| Enzyme | Kava | Warfarin |
|---|---|---|
| CYP1A2 | INHIBITOR (MODERATE) | SUBSTRATE (WEAK) |
| CYP3A4 | INHIBITOR (WEAK) | SUBSTRATE (MODERATE) |
API Reference
GET https://api.truthstack.co/v1/check?c1=Kava&c2=Warfarin
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 12495559
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.