Kava and Methotrexate

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeCONTRAINDICATED
MechanismHEPATIC
Last Reviewed2026-02-15

Summary

Both kava and methotrexate are hepatotoxic. Combined use dramatically increases risk of liver failure. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Kava: CYP1A2 inhibitor (moderate), CYP2D6 inhibitor (moderate), CYP2E1 inhibitor (strong), CYP3A4 inhibitor (weak)

API Reference

GET https://api.truthstack.co/v1/check?c1=kava&c2=methotrexate

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Oxycodone Benzodiazepines + Kava Diazepam + Kava Echinacea + Methotrexate
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.