Kava and Sertraline
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Summary
Kava has GABAergic and possible serotonergic activity. Risk of excessive sedation with SSRIs. Case reports document adverse interactions.
CYP Enzyme Pathway Overlap
Kava and Sertraline share activity on the following CYP enzymes:
| Enzyme | Kava | Sertraline |
|---|---|---|
| CYP2D6 | INHIBITOR (MODERATE) | SUBSTRATE (MODERATE) |
| CYP3A4 | INHIBITOR (WEAK) | SUBSTRATE (WEAK) |
API Reference
GET https://api.truthstack.co/v1/check?c1=Kava&c2=Sertraline
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 11894808
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.