Ibuprofen and Kava

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeSAFETY CONCERN
Last Reviewed2026-02-24

Summary

Both kava and NSAIDs carry hepatotoxicity risk. Combined use increases hepatic burden.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Ibuprofen: CYP2C9 substrate (strong)

Kava: CYP1A2 inhibitor (moderate), CYP2D6 inhibitor (moderate), CYP2E1 inhibitor (strong), CYP3A4 inhibitor (weak)

API Reference

GET https://api.truthstack.co/v1/check?c1=Ibuprofen&c2=Kava

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Methotrexate Kava + Oxycodone Benzodiazepines + Kava Diazepam + Kava
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.