Green Tea Extract and Methotrexate

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismHEPATIC
Last Reviewed2026-02-15

Summary

Both green tea extract (high-dose EGCG) and methotrexate carry hepatotoxicity risk. Additive liver injury potential. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Green Tea Extract: CYP1A2 substrate (moderate), CYP3A4 inhibitor (weak)

API Reference

GET https://api.truthstack.co/v1/check?c1=green%20tea%20extract&c2=methotrexate

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Kava + Methotrexate Echinacea + Methotrexate Ashwagandha + EGCG Green Tea Extract + Pantoprazole Methotrexate + St Johns Wort Green Tea Catechins + Iron Amlodipine + Green Tea Extract Atorvastatin + Green Tea Extract
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.