Fish Oil Omega-3 and Vitamin E
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | pharmacodynamic |
| Last Reviewed | 2026-02-07 |
Summary
1 IU vitamin E per gram fish oil for stability; caution with anticoagulants; stop both 7-10 days pre-op
Higher-Concern Contexts
This interaction may be of particular concern in the following contexts:
- anticoagulant use
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | Fish Oil Omega-3 | Vitamin E |
|---|---|---|---|
| COAGULATION | DECREASE | WEAK | WEAK |
| PLATELET FUNCTION | DECREASE | MODERATE | MODERATE |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
API Reference
GET https://api.truthstack.co/v1/check?c1=fish_oil_omega3&c2=vitamin_e
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.