Amlodipine and Fish Oil
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Limited |
| Interaction Type | BLEEDING RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-10 |
Summary
Monitor closely. 6615 serious adverse events reported with this combination in FDA FAERS. Pharmacovigilance signal, not proof of causation. Discuss with prescriber.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Amlodipine: CYP3A4 substrate (strong)
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | Amlodipine | Fish Oil |
|---|---|---|---|
| BLOOD PRESSURE | DECREASE | STRONG | WEAK |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
What We Don't Know
This interaction has limited evidence. Key gaps may include: direct clinical trial data for this specific combination, dose-response relationships, and long-term outcome data. Absence of evidence is not evidence of absence.
API Reference
Open, unauthenticated. Returns JSON. Developer documentation