Escitalopram and Kava

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Kava has GABAergic activity. Risk of excessive CNS depression with SSRIs. Monitor for sedation.

CYP Enzyme Pathway Overlap

Escitalopram and Kava share activity on the following CYP enzymes:

EnzymeEscitalopramKava
CYP3A4SUBSTRATE (MODERATE)INHIBITOR (WEAK)

API Reference

GET https://api.truthstack.co/v1/check?c1=Escitalopram&c2=Kava

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Methotrexate Kava + Oxycodone Benzodiazepines + Kava Diazepam + Kava
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.