Atorvastatin and CoQ10
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | BLEEDING RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Summary
Statins inhibit HMG-CoA reductase, also required for endogenous CoQ10 synthesis. Statin-induced CoQ10 depletion documented and may contribute to myalgia. Meta-analyses show CoQ10 supplementation reduces statin-associated muscle symptoms. FAERS: 2,233 reports. CoQ10 100-300mg daily commonly recommended alongside statins.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Atorvastatin: CYP3A4 substrate (strong)
API Reference
GET https://api.truthstack.co/v1/check?c1=atorvastatin&c2=coq10
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 29555106
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.