Apixaban and Omega-3

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeBLEEDING RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

High-dose fish oil has antiplatelet and anticoagulant effects. Combining with apixaban may increase bleeding risk. Monitor for bruising and bleeding at doses above 3g/day. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Apixaban: CYP3A4 substrate (moderate), P-gp substrate (moderate)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionApixabanOmega-3
COAGULATIONDECREASESTRONGWEAK

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=apixaban&c2=omega3

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Apixaban + CBD Apixaban + Curcumin Amlodipine + Fish Oil Atorvastatin + Fish Oil Citalopram + Fish Oil Cyclosporine + Fish Oil Duloxetine + Fish Oil Escitalopram + Fish Oil
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.