Apixaban and Kava

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeMETABOLIC
MechanismMETABOLISM
Last Reviewed2026-02-24

Summary

Kava inhibits multiple CYP enzymes including CYP3A4. May increase apixaban levels. Monitor for bleeding.

CYP Enzyme Pathway Overlap

Apixaban and Kava share activity on the following CYP enzymes:

EnzymeApixabanKava
CYP3A4SUBSTRATE (MODERATE)INHIBITOR (WEAK)

API Reference

GET https://api.truthstack.co/v1/check?c1=Apixaban&c2=Kava

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Methotrexate Kava + Oxycodone Benzodiazepines + Kava Diazepam + Kava
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.