Serrapeptase and Warfarin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | BLEEDING RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-16 |
Summary
Serrapeptase has fibrinolytic and anti-inflammatory properties that may affect coagulation. Combined with warfarin, literature flags increased bleeding risk. Discuss with your prescriber or pharmacist.
Higher-Concern Contexts
This interaction may be of particular concern in the following contexts:
- anticoagulant use
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Warfarin: CYP1A2 substrate (weak), CYP2C9 substrate (strong), CYP3A4 substrate (moderate)
API Reference
GET https://api.truthstack.co/v1/check?c1=Serrapeptase&c2=Warfarin
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.