Omeprazole and Resveratrol

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACOKINETIC
Last Reviewed2026-02-16

Summary

Resveratrol modulates CYP3A4 and other CYP enzymes involved in omeprazole metabolism. Polyphenol-mineral chelation may compound PPI-related nutrient malabsorption with long-term combined use.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Omeprazole: CYP2C19 substrate (strong), CYP3A4 substrate (moderate)

API Reference

GET https://api.truthstack.co/v1/check?c1=Omeprazole&c2=Resveratrol

Open, unauthenticated. Returns JSON. Developer documentation

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.