Norethindrone and Semaglutide

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeABSORPTION INTERFERENCE
MechanismABSORPTION
Last Reviewed2026-02-24

Summary

GLP-1 agonists delay gastric emptying, potentially reducing oral contraceptive absorption. Literature flags possible reduced efficacy. Discuss backup contraception with your prescriber or pharmacist.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Semaglutide: CYP3A4 substrate (weak)

API Reference

GET https://api.truthstack.co/v1/check?c1=Norethindrone&c2=Semaglutide

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Levothyroxine + Semaglutide Calcium + Semaglutide Fish Oil + Semaglutide Folate + Semaglutide Iron + Semaglutide Magnesium + Semaglutide Melatonin + Semaglutide Alpha Lipoic Acid + Semaglutide
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.