NAC and NAD+
Supplement–drug interaction evidence from the TruthStack database.
| Severity | INFO |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | COMPLEMENTARY |
| Last Reviewed | 2026-02-24 |
Summary
NAC replenishes glutathione (Phase II) while NAD+ supports Phase I reactions and sirtuin activation. Complementary cellular defense. No adverse interaction documented.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
NAC: CYP2E1 inhibitor (weak)
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | NAC | NAD+ |
|---|---|---|---|
| OXIDATIVE STRESS | DECREASE | STRONG | MODERATE |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
API Reference
GET https://api.truthstack.co/v1/check?c1=NAC&c2=NAD%2B
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.