Metformin and Turmeric

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeANTAGONISTIC
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Curcumin has documented glucose-lowering effects that may be additive with metformin. Curcumin also inhibits CYP enzymes. FAERS: 750 reports. Monitor blood glucose. Some evidence suggests beneficial combination but requires clinician oversight.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Metformin: P-gp substrate (moderate)

Turmeric: CYP1A2 inhibitor (weak), CYP2C9 inhibitor (moderate), CYP2D6 inhibitor (weak), CYP3A4 inhibitor (moderate)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionMetforminTurmeric
BLOOD GLUCOSEDECREASESTRONGMODERATE

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=metformin&c2=turmeric

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 31249528

Related Interactions

Berberine + Metformin Biotin + Metformin Black Cohosh + Metformin Calcium + Metformin CoQ10 + Metformin Apixaban + Curcumin Clopidogrel + Curcumin Curcumin + Rivaroxaban
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.