Metformin and NAD+
Supplement–drug interaction evidence from the TruthStack database.
| Severity | INFO |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Summary
Metformin activates AMPK which increases NAD+ biosynthesis. Complementary effects on cellular energy metabolism. No adverse interaction documented.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Metformin: P-gp substrate (moderate)
API Reference
GET https://api.truthstack.co/v1/check?c1=Metformin&c2=NAD%2B
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 31804424
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.