Lorazepam and Melatonin

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Both melatonin and lorazepam have sedative effects. Combining may increase drowsiness. Discuss with your prescriber or pharmacist.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Lorazepam: CYP3A4 substrate (weak)

Melatonin: CYP1A2 substrate (strong), CYP2C19 substrate (weak)

API Reference

GET https://api.truthstack.co/v1/check?c1=lorazepam&c2=melatonin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Kava + Lorazepam Amlodipine + Melatonin Atorvastatin + Melatonin Citalopram + Melatonin Cyclosporine + Melatonin Duloxetine + Melatonin Escitalopram + Melatonin Fluoxetine + Melatonin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.