Lisinopril and Magnesium

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Magnesium has independent vasodilatory and mild antihypertensive effects. Combined with ACE inhibitors, additive blood pressure lowering possible. ACE inhibitors may promote magnesium retention. FAERS: 11,533 reports. Monitor blood pressure. Generally well-tolerated at standard supplemental doses.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Lisinopril: CYP3A4 substrate (weak)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionLisinoprilMagnesium
BLOOD PRESSUREDECREASESTRONGMODERATE

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=lisinopril&c2=magnesium

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 27402061

Related Interactions

Lisinopril + Potassium Biotin + Lisinopril Black Cohosh + Lisinopril Calcium + Lisinopril Cbd + Lisinopril CoQ10 + Lisinopril Echinacea + Lisinopril Fish Oil + Lisinopril
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.