Ibuprofen and St. Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeMETABOLIC
MechanismMETABOLISM
Last Reviewed2026-02-24

Summary

Induces CYP2C9, primary ibuprofen metabolic pathway. May reduce ibuprofen efficacy.

CYP Enzyme Pathway Overlap

Ibuprofen and St. Johns Wort share activity on the following CYP enzymes:

EnzymeIbuprofenSt. Johns Wort
CYP2C9SUBSTRATE (STRONG)INDUCER (MODERATE)

API Reference

GET https://api.truthstack.co/v1/check?c1=Ibuprofen&c2=St.%20Johns%20Wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Methylene Blue + St. John'S Wort Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort Citalopram + St Johns Wort Escitalopram + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.