Ibuprofen and Melatonin

Supplement–drug interaction evidence from the TruthStack database.

SeverityLOW
Evidence TierLimited
Interaction TypeNEUTRAL
Last Reviewed2026-02-24

Summary

No significant interaction documented.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Ibuprofen: CYP2C9 substrate (strong)

Melatonin: CYP1A2 substrate (strong), CYP2C19 substrate (weak)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionIbuprofenMelatonin
PLATELET FUNCTIONDECREASEMODERATEWEAK

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

What We Don't Know

This interaction has limited evidence. Key gaps may include: direct clinical trial data for this specific combination, dose-response relationships, and long-term outcome data. Absence of evidence is not evidence of absence.

API Reference

GET https://api.truthstack.co/v1/check?c1=Ibuprofen&c2=Melatonin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Amlodipine + Melatonin Atorvastatin + Melatonin Citalopram + Melatonin Cyclosporine + Melatonin Duloxetine + Melatonin Escitalopram + Melatonin Fluoxetine + Melatonin Lansoprazole + Melatonin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.