Fluvoxamine and Yohimbine

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Yohimbine has alpha-2 antagonist and weak MAOI activity. Combined with Fluvoxamine, literature flags increased serotonergic and cardiovascular effects. Monitor blood pressure and discuss with your prescriber or pharmacist.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Fluvoxamine: CYP1A2 inhibitor (strong), CYP2C19 inhibitor (strong)

API Reference

GET https://api.truthstack.co/v1/check?c1=Fluvoxamine&c2=Yohimbine

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Fluvoxamine + St Johns Wort Fluvoxamine + Garcinia Cambogia Antihypertensive Drugs + Yohimbine Citalopram + Yohimbine Escitalopram + Yohimbine Fluoxetine + Yohimbine Paroxetine + Yohimbine Sertraline + Yohimbine
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.