Fluoxetine and Sam-E

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSEROTONERGIC RISK
MechanismSEROTONERGIC
Last Reviewed2026-02-15

Summary

SAM-e increases serotonin synthesis. Fluoxetine blocks reuptake. Combined equals serotonin syndrome risk. Fluoxetine has long half-life requiring extended washout. Discuss with your prescriber or pharmacist.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Fluoxetine: CYP2C9 inhibitor (moderate), CYP2D6 inhibitor (strong), CYP2D6 substrate (strong)

API Reference

GET https://api.truthstack.co/v1/check?c1=fluoxetine&c2=sam-e

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Cobalamin B12 + SAMe Folate B9 + SAMe Methylene Blue + SAM-E 5-HTP + SAM-E SAM-E + Vitamin B12 SAM-E + Vitamin B9 Fluoxetine + St Johns Wort 5 Htp + SAMe
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.