Fluoxetine and Garcinia Cambogia

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSEROTONERGIC RISK
MechanismSEROTONERGIC
Last Reviewed2026-02-24

Summary

Garcinia cambogia (hydroxycitric acid) may increase serotonin levels. Combined with Fluoxetine, literature flags potential serotonin toxicity risk. Discuss with your prescriber or pharmacist.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Fluoxetine: CYP2C9 inhibitor (moderate), CYP2D6 inhibitor (strong), CYP2D6 substrate (strong)

API Reference

GET https://api.truthstack.co/v1/check?c1=Fluoxetine&c2=Garcinia%20Cambogia

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Fluoxetine + St Johns Wort Biotin + Fluoxetine Calcium + Fluoxetine Cbd + Fluoxetine CoQ10 + Fluoxetine Fish Oil + Fluoxetine Fluoxetine + Folate Citalopram + Garcinia Cambogia
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.