Finasteride and Saw Palmetto

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Both saw palmetto and finasteride inhibit 5-alpha-reductase, reducing DHT. Combined use may produce additive anti-androgenic effects and increase sexual side effect risk.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Finasteride: CYP3A4 substrate (moderate)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionFinasterideSaw Palmetto
DHTDECREASESTRONGMODERATE

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=Finasteride&c2=Saw%20Palmetto

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 22429846

Related Interactions

Amlodipine + Saw Palmetto Atorvastatin + Saw Palmetto Lansoprazole + Saw Palmetto Levothyroxine + Saw Palmetto Lisinopril + Saw Palmetto Losartan + Saw Palmetto Metformin + Saw Palmetto Metoprolol + Saw Palmetto
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.