Copper and Zinc
Supplement–drug interaction evidence from the TruthStack database.
| Severity | CRITICAL |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SAFETY CONCERN |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-24 |
Summary
Zinc and copper compete for absorption via metallothionein binding. Chronic zinc (>40mg/day) depletes copper stores, potentially causing copper deficiency anemia, neutropenia, and irreversible neurological damage. Well-established. If supplementing zinc long-term, add copper at ~1mg per 15mg zinc ratio.
API Reference
GET https://api.truthstack.co/v1/check?c1=Copper&c2=Zinc
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 2407098
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.