Calcium and Magnesium

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeABSORPTION INTERFERENCE
Mechanismpharmacokinetic
Last Reviewed2026-02-07

Summary

Consider separating high doses by 2+ hours; or take combined Ca/Mg supplement. Optimal ratio: Ca:Mg approximately 2:1

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionCalciumMagnesium
BLOOD PRESSUREDECREASEWEAKMODERATE

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=calcium&c2=magnesium

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Amlodipine + Calcium Atorvastatin + Calcium Calcium + Citalopram Calcium + Cyclosporine Calcium + Doxycycline Calcium + Duloxetine Calcium + Escitalopram Calcium + Fluoxetine
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.