Ashwagandha and Semaglutide

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-24

Summary

Ashwagandha has glucose-lowering properties. Additive hypoglycemic effects with GLP-1 agonists possible.

CYP Enzyme Profiles

Published CYP enzyme data for compounds in this interaction:

Semaglutide: CYP3A4 substrate (weak)

Shared Pharmacodynamic Endpoints

Both compounds influence the same physiological endpoints in the same direction:

EndpointDirectionAshwagandhaSemaglutide
BLOOD GLUCOSEDECREASEMODERATESTRONG

Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.

API Reference

GET https://api.truthstack.co/v1/check?c1=Ashwagandha&c2=Semaglutide

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 32020816

Related Interactions

Levothyroxine + Semaglutide Ashwagandha + Iodine Calcium + Semaglutide Ashwagandha + EGCG Fish Oil + Semaglutide Folate + Semaglutide Iron + Semaglutide Magnesium + Semaglutide
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.