Alprazolam and Melatonin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-15 |
Summary
Both melatonin and alprazolam have CNS depressant effects. Combining may increase sedation and impair coordination. Use caution. Discuss with your prescriber or pharmacist.
CYP Enzyme Profiles
Published CYP enzyme data for compounds in this interaction:
Alprazolam: CYP3A4 substrate (strong)
Melatonin: CYP1A2 substrate (strong), CYP2C19 substrate (weak)
Shared Pharmacodynamic Endpoints
Both compounds influence the same physiological endpoints in the same direction:
| Endpoint | Direction | Alprazolam | Melatonin |
|---|---|---|---|
| CNS DEPRESSION | INCREASE | STRONG | MODERATE |
Cumulative effect on shared endpoints may exceed individual compound profiles. This is relevant to discussion with a prescribing clinician.
API Reference
GET https://api.truthstack.co/v1/check?c1=alprazolam&c2=melatonin
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.