Acetaminophen and NAC
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Summary
NAC is the established clinical antidote for acetaminophen toxicity, replenishing glutathione stores. FDA-approved for acetaminophen overdose. In non-toxic doses, NAC may provide hepatoprotection.
CYP Enzyme Pathway Overlap
Acetaminophen and NAC share activity on the following CYP enzymes:
| Enzyme | Acetaminophen | NAC |
|---|---|---|
| CYP2E1 | SUBSTRATE (STRONG) | INHIBITOR (WEAK) |
API Reference
GET https://api.truthstack.co/v1/check?c1=Acetaminophen&c2=NAC
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 24741706
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.